الفهرس 
Chemical structure of prostaglandinsOnly 14 pages are availabe for public view
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Abstract
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SUMMARY AND CONCLUSION
In this study we are aiming to estimate the level of
prostaglandins in patients with ischaemic heart diseases
before and after aspirin therapy, and we investigated the
possible role of aspirin therapy in management of
ischaemic heart disease.
Our results demonstrated that prostaglandin E2 levels
were significantly higher ( P < 0.25) in patients with
ischaemic heart disease than in normal subjeots. Also
there was a signifioant deorease in PGE2 plasma level after
aspirin therapy 300 mg/ every other day for 2 weeks
compare d to those befor therapy (p < o,05). from the
clinical point Of view, the patients under aspirin therapy
showed a deoline in their exeroise toleranoe.
Our results using treadmill exeroise tolerance test
demonstrated a deorease in the tolerance in 18 out of
20 patients ofter aspirin.
This decrease was found to be statistically significant
(P<o.Ol). It may be that in such patients stresses
that inccease myocardial oxygen demand would be less
tolerated in presence of aspirin.
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One point that must be emphasized, is that our
results do not permit ·.d~:t;p.Ueconclusion about
precise effect of aspirin in management of ischaemic
heart disease, because we did not measure the coronary
sinus PGs level.
Laa t Ly we ”,dvise to stop the use of l:Ialicyl”t,es
in treatment of ischaemic he”,rt diseases until the
discovery of new specific drugs blocking the vasoconstrictor
prostaglandins.