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Abstract subject of th s thesis was the study of vascular changes, venous and art rial, that may be encolUltered in sections of the liver cases of periportal. bilharzial hepatic fibrosis • For that purpose, tissue b~ocks were obtained from 37 autopsy cases that show d evidence of bilharzial hepatic fibrosis; along with t sue blocks from six apparently normal livers that wer used as control material • Clinical data as well as autopsy findings were used to identify Cfrses show ng evidence of portal hypertension. Tissue blocks we e routinely processed , paraffin embedded, sectioned stained with H & E, Masson Trichrome and Orcein sta • Microscopic ation aimed at identifying all pathological lesions; hat were classified as follows : lesions of small port veins and those of large one • For that purpose, the accompanying hepatic arterial branches were measured us~g calibrated eye piece • Accordingly, identified, namely S patterns of hepatic lesions were .er’s fibrosis ( coarse periportal fibrosis ) in which the esions involve both small and large portal triads; and non-Symmer’ s ( fine bilharzia1 periportal fibrosis ) c aracterized by predominant involvement of small po al triads and notably sparing large one • 3 the va.scular lesions encountered ilharzial granuloma ), phleb1 tis , patic thrombophlebitis, arterie.1isation and angiomatoid While in non-Symmer’s cases pseudotubercle ( bilhar ial granuloma ), phlebitis ami phlebosclerosis ,were t e venous lesions observed. In Symmer’s cases were pseudotubercles ( Correla.tion of p hological vascular venous lesions with available infonna ion of portal hypertension reveal.ed the following : es of portal hypertension were associated with characteristic ot Symmer’s fibrosis only ; (2) gory, some of lesions were attributed to the primary disease only such as : (a) Intravascular granuloma ( pseudotube cle ); (b) phlebitis; (c) phlebosclerosis; (d) thrombohlebitis and (e) angiomatoid , whereas arterialisatio was believed to be directly related to the effect of port hypertension on venous wall structure • Arterial changes ”ncluding elasto-fibrosis of intima with reduplicat”on of internal elastic lamina, medial hypertrophy and adventitial fibrosis were found also in association wi mentioned venous lesions in Symmer’s cases. M4 Morphometric stu Y of hepatic arterial branches in S~ner’s cases reveale significant luminal dilatation of arterioles less than I 0 urn, while small arteries between 200 and 300 um showed ignificant luminal narrowing • The significance of these arterial lesions was thought to be a reflection to arterial hypertension in hepatic circulation t at may be related to increased arterial hepatic blo flow or sinusoidal hypertension or both 0 |