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Abstract 66 SUMMARY AND CONCLUSION The present thesis was devoted to study the pharmacological action of the dry extract of ginseng powder , which has the upper hand in the fa~ east medicine especially in China, Korea and Japan. It is used for the treatment of anaemia, diabetes, gastritis, sexual impotance and other conditions associated with old age • In the present work, the effect of serial doses of the dry extract on different isolated tissues from various animals and the effect of the dry extract on the response of these tissues to suitable agonists were carried out • Moreover, the acute effect of the extract on blood glucose level was studied in normal and experimentally-induced diabetic mice • It is evident from the present study that serial doses of the extract from 0.5 ug/ml to 80 ug/ml did not affect neither the normal contractions nor the epinephrineinduced positive inotropic effect in both isolated frog’s and rabbit’s heart. Also, the depressant effect of acetylcholine did not change by concomitant administration of ginseng extract 67 Doses of 20 , 40 and 80 ug/ml produced no effect on the ileum and tracheal spiral strip of guinea pig and nonpregnant rat uterus, also the contractions induced in these preparations in response to acetylcholine was not changed by combined administration of ginseng • Epinephrine-induced contractions of rabbit’s aortic strip; epinephrine-induced inhibitory effect on the contractions of rabbit’s intestine did not by concomitant administration of ginseng extract • The response of the isolated toad’s rectus abdominis to acetylcholine did not change by addition of the extract ( 10 to 80 ug / ml l. The control was devoid of any change • Lastly, the dry extract of ginseng in a dose of 0.4 mg/kg body weight, dissolved in 0.5 ml distilled water did not produce significant change in the blood glucose level of both normal albino mice and animals with alloxan-induced diabetes . from this study, it may be concluded that ginseng dry extract powder has no side effects and the treatment with ginseng requires a long-term period to achieve the therapeutic effects . |