الفهرس 
Review of LiteratureOnly 14 pages are availabe for public view
 |  | from | 140 |  |  |
| | | from | 140 | | |
Abstract
Study design: prospective, clinical observational study.
Objective: to study the effect of oral and transdermal hormone replacement therapy (HRT) in Egyptian postmenopausal bone mineral density, as assessed by densitometry.
Subjects: The study included 80 postmenopausal women for 1 to 7 years from the same social class (middle class), with no chronic disease and no contraindication to HRT. According to the route of administration of HRT women were divided into 2 groups: Transdermal HRT group: Included 40 women who received transdermal HRT in the form estracombi 50 patches (Novartis-Switherland). Each package contains 8 patches, the first 4 patches each contains estraderm 50 (50 microgram estradiol), and the second 4 patches each contains estragest (50 microgram estradiol and 250 microgram norethestrone acetate).
Summary and Conclusion Oral HRT group: Included 40 women who received oral HRT in the form of Prempak C 0.625 mg. Each package contains 28 tables, each containing 0.625 conjugated estrogen, and 12 of these tablets each contains 0.15 mg norgestrel.
Method: One densitometry of the hip femur neck and lumber vertebra, (L I -L4) was done to measure bone mineral density (BMD) and T-score for each women before start of HRT as a baseline level. Women were followed up clinically for one year. After one year of HRT, another lumber and hip densitometry was done to see the effect of HRT on BMD and T-score.
Results: The present study reveled the following:
1- Both trandermal and oral hormone replacement therapy for 12 months prevented bone loss, and increased bone mineral density and improved the T-score in both the femur neck and the lumber vertebrae. However the mean increase in BMD and T-score was not significant.
-95-
Summary and Conclusion
2-There was a percent increase in both BMD and in the T-score for femur and vertebrae, from baseline levels.
3-The effect of HRT was more on the spine than on the hip.
4-The was no statistically significant difference between the effect of oral and transdermal HRT after one year of treatment on BMD and T-score in both femur and vertebrae.
5-There was a positive correlation between femoral bone density and femoral T-score and both body weight and body mass index.
6-There was a positive correlation between vertebral bone density and vertebral T-score and body mass index, and between vertebral T-score and body weight there was negative correlation between vertebral T-score and parity.
-96-
Summary and Conclusion
CONCLUSION
HRT (E & P) after the menopause could prevent bone loss, that naturally increases with the progress of menopause, and in the meantime numerically increased BMD and T-score BMD in both femur LI—Lt and femur neck .