الفهرس 
Review of LiteratureOnly 14 pages are availabe for public view
 |  | from | 197 |  |  |
| | | from | 197 | | |
Abstract
Recurrent pregnancy loss has always been a frusb’ating problem for
both the patient and the physician. However, recent advances in tlle
mdentan.ding of the palhophysiolO;gy of recurrent pregnamcy loss has
diminished the number ofwtexplained losses (Coulam, 1986).
The immane system msa complex integrated system that bas evolved to
protect the individual Hom non-self tissue yet the maternal immune system
does not normally react adversely to the conceptus. The embryo, fetus, and
trophoblast are natura) immuno]vgica! targets due to their paternally inherited
gene products and tissue S\l¢cific differentiation antigens. An lInmunologjcal
etiology for habitual abortion has been proposed for many couples with an
otherwise unexplained etiology for their reproductive failure (Hill 81Id
Ravnikar. 1990).
The production of autoantibodies dlirected against membrane
phospbolipidls has been strongly associated with a variety of medical disoruers
inclUding recurrent pregnancy 1M$, thromboembolic disease,and
thrOtllbocytoperua (Branch et al., 1985).
This antiphospholipid antibodies may be secoadary to autQimmune
disorders (mainly systemic lupus erythematosus), but they have also been
described in the absence of underlying disorders.