الفهرس | Only 14 pages are availabe for public view |
Abstract Our study involved 60 sexually mature, healthy. isolated, non-pregnant albino female rabbits. weighing two to three kilograms each. The rabbits were housed individually for two weeks prior to surgery. to be sure that they were not pregnant. Each rabbit was subjected to a standard injnry to stimulate adhesion formation. The rabbits were randomly divided into four groups, each was made of 15 rabbits. The rabbits of each group received one of the drugs to be tested for prevention of postoperative adhesion formation/reformation. Each drug was administered intramuscularly. 30 minutes prior to surgery, then every 8 hours for 3 successive days. Group I: Rabbits in the control group received saline injections. 1 ml per dose. Group II: Rabbits received dexamethasone. 4mg/kg body weight per dose. Group III: Rabbits received promethazine. 7.5 mg/kg body weight per dose. Group IV: Rabbits received voltaren. 7.5 mg/kg body weight per dose. Four weeks later, a second laparotomy was done to assess the adhesiion formation and lyse these formed adhesions. Rabbits that developed intraperltoneal adhesions and had adhesion lysis were again divided into 4 groups and were given the previously mentioned drug regimens. All the results were compared by the (Student t-test). The study showed that each of dexamethasone and voltaren was effective in reduction of postoperative adhesion formation I reformation. However, there was no statistically significant reduction of the adhesion formation I reformation with the use of promethazine. (1) Dexamethasone is effective in reduction of postoperative adhesion formation I reformation. (2) Voltaren is effective in reduction of postoperative adhesion formation I reformation. (3) The reduction of postoperative adhesion formation I reformation was not significant with promethazine. compared to control group. |