الفهرس 
Material and methodsOnly 14 pages are availabe for public view
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Abstract
With the discovery of Helicobacter pylori in 1983 by Marshall and
Warren, considerable interest has been expressed in relation to its role in
many gastroduodenal and extra-gastric disease.
H.pylori is commonly associated with gastric and duodenal ulcer.
Recent studies suggest that it plays an important cofactor in the
development of gastric adenocarcinoma and primary antral B-cell
lymphoma. Complete regression of these lesions has been documented
following eradication of H.pylori by antibiotic therapy.
The observation that eradication of H.pylori cures peptic ulcer
disease and that screening for H.pylori infection may improve the
diagnostic yield of endoscopy is leading to a major re-evaluation of the
optimal management of those who harbour the infection.
Prior to the first description of the 13114C urea breath test (13114C_
UBT), the diagnosis ofH.pylori infection had usually been established by
histology, culutre, or biopsy urease test, or non-invasively by serology.
Although 13C/urea breath test is a simple, practical and highly
accurate non invasive but needs special laboratory and special
technicians in addtion to its high cost.
Detection of H.pylori by serology reflects only previous exposure
to H.pylori and may not indicate active or current infection. In additon,
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because antibody titers can take up to six months to fall after successful
treatment, serology tests can not readily be used to assess the efficacy of
new treatment regimens or novel antimicrobial agents specifically
developed for the treatment of H.pylori infection.
In this study, we used two different diagnostic modalities,
histopathological examination and HPSA to detect H.pylori in patients
before and after treatment. The main task of this work is assessment of
HPSA as a diagnostic tool before and after treatment of H.pylori
infection.
We studied 30 patients with upper gastro intestinal symptoms as
nausea, vomiting, fullness, epigastric pain, heart burn and haematemesis.
Complete clinical examination, laboratory investigations,
ultrasonography and upper gastrointesinal endoscopy with biopsies taken
from different sites of stomach and stool specimens for HPSA were done
to all patients. Re-endoscopy and biopsies together with HPSA were done
for cases with H.pylori after one month form therapy.
OUf results revealed that there is no significant difference In
prevalence ofH.pylori and age.
As regard sex, we did not find significant difference in prevalence
ofH.pylori between males and females.
The upper gastrointestinal symptoms showed no statiscially
significance in prevalence ofH.pylori infection.
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Validation characteristics of the HPSA were good where the values
were as follows sensitivity: 84.2%, specificity: 81.8%, accuracy: 83.3%
and positive predictivity : 88.9%.
Hence, the results of this study are supporting the general concept
that HPSA is a simple, accurate and non invasive test for detection of
H.pylori infection and monitoring the e~adication of H.pylori infection
after treatment.