الفهرس 
Review of LiteratureOnly 14 pages are availabe for public view
 |  | from | 108 |  |  |
| | | from | 108 | | |
Abstract
· .
\
SUMMARY & CONCLUSION
In the last few decades, five hepatitis viruses (A to E) have been
well characterized and few mote putative agents (F,G&Z) are likely to be
added to the existing alphabet.
-,
The pathogenesis of different types of viral hepatitis and the
mechanisms underlying hepato,cellular injury are poorly understood
However , the degree of hepatocellular necrosis seen in viral hepatitis
appears to depend on the host’s immune response to infected hepatocytes ,
especially in viruses which are known not to have any or to have little
cytopathic effect
lL-8 & GM-CSF have been involved in pathogensis of diversity of
liver conditions including viral hepatitis, they are a principal mediator of
inflammation and cellular inllTIun.e.,response.
The aim of the present work is to study serum levels of IL-8 and
GM-CSF in chronic hepatitis B&C viral infection.
30 patients with chronic viral hepatitis and 10 age- and sex- matched
controls were selected for this study. Patients were divided into 3 groups
according to aetiology, group I ( patient with chronic HBV) group II (
patients with chronic HCV) and group 11I( patients with concomittent
chronic HBV and HCV ).
-82-
/\11 patients were subjected to the following,
* Through history taking,
* Clinical examination,
,
* Routine laboratory mvestig<tti-o,ns ,
* Liver function tests includmgserum bilirubin and serum enzymes (SOOT
, SOPT & alkaline phosphatase ) in addition to serum protein, albumen
and prothrombin time .
*Serological testing of viral hepatitis markers.
_ HBsAg and anti- HBc ( IgM-IgG )
_ HCV Abs using the ELISA technique.
*Then serum IL-8 and OM-CSF were estimated using the ELISA
technique
In the present work the mam symptoms and SIgnS vcre
hepatomegaly (60%)
jaundice ( 46%). Bilirubin showed significant
increase in the three studied groups as compared to control. SGOT and
SGPT
in the three studiecf’lroups were significantly increased in
comparison to control group.
There were a highly significant difference between IL-8 values in
the three studied groups of patients and control brroups .There were a
Sib’11ificant correlation between IL-8 values and bilirubin, SGPT, and
SGOT.
There were a highly significant difference between GM-CSF
. ,i ,~ values in the tlrree studied groups of patients and control groups .There
were a significant correlation between GM-CSF values and bilirubin,
SGPT , and SGOT
-83-
So it can be concluded that IL-8 and GM-CSF are significantly
increased in patients with chronic viral hepatitis and levels of IL-8 and
GM-CSF are correlated significantly with the severity of the activity of
viral infection which determined by increased level of SGPT , SGOT and ,
serum bilirubin IL-8 has chemoattractant effect for neutrophils and GMCSF
stimulates proliferation and maturation of myeloid progenitor cells
giving rise to neutrophils andmonocytes . So they increase the number of
phagocytic cells and such they may playa significant role in host
defence and pathogenesis of chronic viral hepatitis.
\ .
.-.