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Abstract SUMMARY ANp CONCLUSION A positIve famIly history of myoctlrditll Infarction is rC’C”ognizedas one of the corontlry ril<’Kftlctors and seems to be related to serum lipids. lipoproteins and apolipoproteins. To assess the potentIal use of the lipids. lipoproteIns and apolipoproteins as risK factor for coronary artery diseases (CAD) in the offsprings of myocardial infarction (MI) patients. 30 asymptomatic offsprings (15 males and 15 females) of MI patients and also 30 healthy subjects (15 mals and 15 females) of the same age range serving as controls had been subjected to the fo II owi ng: * Thorough medical history takIng and clinical examination including electrocardiography (EeG). * Evaluation of blood sugar levels both durIng fasting and after mixed meal. * Estimation of serum levels of uric aCld. * Estimation of serum levels of triglycerides. total cholesterol. low density lipoprotein cholesterol (LDL”r-) and high density lipoprotein cholesterol (HDL-c). * De t er’m i ne t aon of serum levels of apol ipoprotein A (Apo” A) and apolipoprotein B (Apo-B). The results of the study revealed that male offsprIngs of MI patients showed lipid and apolipoprotein abnormalities In the f·:yrr, cf slg:lificant lowering of serum HDL-c. Apo-A and re t i o or Sunvnary and Conclusion -103’ serum Apo-A/serum Apo-B with significant elevatIon of serum total cholesterol/serum HDL-c ratio. serum LDL-c/serum HDL-c ratIO. serum levels of total cholesterol. triglycerides and LDLr followed by significant elevation of serum Apo-B compared to ’’’;”n ·:>ge-matched controls. While. female offsprings of MI patlent8 showed lipid abnormalities in the form of SIgnificant lowering of serum HDL-c with significant elevation of serum triglycerides. total cholesterol. serum total cholesterol/serum HDL-c ret i o and serum LOL-e/sel’um HDL-c ratio f,)llowed by sl~nificant elevation of serum LDL-c compared to their agematched controls. But. serum levels of Apo-A. Apo-B and serum ApC-A/ serum Apo-B ratio showed no significant difference from those of their age-matched controls. These lipid and apolipoprotein abnormalities in the sibilings of HI patients could explain the clustering of HI in families and could be attributed to genetic trait since environmental risk factors known to affect serum lipids and apolipoproteins were not present in those offsprings. Hence. we could concluded that. among Egyptians serum lipid abnormalities are eVident among offsprings of MI patients Whether male or female. But. serum apolipoprotein abnormalities are evident among the male offsprings only and not the female ones. So. among Egyptians. the serum levels of Apo-A. Apo-B and their ratio could be considered as sensitive index for identifying risk subjects among the offsprings of HI patients.like other lipid parameters but. to a lesser extent as they show slgnificant difference in males only and not in the females. |