الفهرس 
LipoproteinsOnly 14 pages are availabe for public view
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Abstract
SUMMARY ANp CONCLUSION
A positIve famIly history of myoctlrditll Infarction is
rC’C”ognizedas one of the corontlry ril<’Kftlctors and seems to be
related to serum lipids. lipoproteins and apolipoproteins.
To assess the potentIal use of the lipids. lipoproteIns and
apolipoproteins as risK factor for coronary artery diseases
(CAD) in the offsprings of myocardial infarction (MI) patients.
30 asymptomatic offsprings (15 males and 15 females) of MI
patients and also 30 healthy subjects (15 mals and 15 females)
of the same age range serving as controls had been subjected to
the fo II owi ng:
* Thorough medical history takIng and clinical examination
including electrocardiography (EeG).
* Evaluation of blood sugar levels both durIng fasting and
after mixed meal.
* Estimation of serum levels of uric aCld.
* Estimation of serum levels of triglycerides. total
cholesterol. low density lipoprotein cholesterol (LDL”r-)
and high density lipoprotein cholesterol (HDL-c).
* De t er’m i ne t aon of serum levels of apol ipoprotein A (Apo”
A) and apolipoprotein B (Apo-B).
The results of the study revealed that male offsprIngs of MI
patients showed lipid and apolipoprotein abnormalities In the
f·:yrr, cf slg:lificant lowering of serum HDL-c. Apo-A and re t i o or
Sunvnary and Conclusion -103’
serum Apo-A/serum Apo-B with significant elevatIon of serum
total cholesterol/serum HDL-c ratio. serum LDL-c/serum HDL-c
ratIO. serum levels of total cholesterol. triglycerides and LDLr
followed by significant elevation of serum Apo-B compared to
’’’;”n ·:>ge-matched controls. While. female offsprings of MI
patlent8 showed lipid abnormalities in the form of SIgnificant
lowering of serum HDL-c with significant elevation of serum
triglycerides. total cholesterol. serum total cholesterol/serum
HDL-c ret i o and serum LOL-e/sel’um HDL-c ratio f,)llowed by
sl~nificant elevation of serum LDL-c compared to their agematched
controls. But. serum levels of Apo-A. Apo-B and serum
ApC-A/ serum Apo-B ratio showed no significant difference from
those of their age-matched controls.
These lipid and apolipoprotein abnormalities in the
sibilings of HI patients could explain the clustering of HI in
families and could be attributed to genetic trait since
environmental risk factors known to affect serum lipids and
apolipoproteins were not present in those offsprings.
Hence. we could concluded that. among Egyptians serum lipid
abnormalities are eVident among offsprings of MI patients
Whether male or female. But. serum apolipoprotein abnormalities
are evident among the male offsprings only and not the female
ones. So. among Egyptians. the serum levels of Apo-A. Apo-B and
their ratio could be considered as sensitive index for
identifying risk subjects among the offsprings of HI patients.like other lipid parameters but. to a lesser extent as they show
slgnificant difference in males only and not in the females.