الفهرس 
Respiratory distress syndromeOnly 14 pages are availabe for public view
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Abstract
RespifatQry distress syndrome (RDS) is one of the most common
causes of d.eath in the first days of life. Pulmonary surfactant deficiency is
thought to have a primary role in its pathogenesis.
This study was done to findout the relation between the level of
thyroid hormones and the incidence of RDS. This study included 40 cases
suffering from ROS bom between 27 and 36 weeks’gestation, their age
ranged from 1-21 days and taken from the intensive care units nf
Damanhour and EI-Mowasha hospitals. Also, 20 healthy infants were studied
as controls.
RDS infants were defined by clinical and redio!ogical criteria and
controls were defined as non asphyxiated infants delivered vaglnailv after
spontaneous onset of labour.
Thyroid function tests including serum triiodothyronine (T~L serum
thyroxine IT 41 and thyroid stimulating hormone (TSHI, in addition to alpha!
antitrypsin were done for all infants.
Enzyme linked immunoassay method IELlSA) was used for estimation
of thymid hormones wllile estimation of alpha 1 antitrypsin was done using
radial lmmunodiffusion method { Kits were provided by Bohring Hoechst
Institute, Germany). The difference in tne results of infants with and without
RDS was statisticiiiiv analyzed using IBM computer program (Stat-G).
There was significant reduction of T3 levels in infants suffering from
RDS. also. we found that T.,. levels were significantly decreased in RDS
infants.
On tile other hand. TSHconcentrations showed no significant changes.
Serum levels of alpha, antitrypsin in ADS infants ware slightly but
significantlv lower than those of the controls.
The fall in T:; levels seems to be due to a reduction of T. to T:;
conversion and the fall in T4 levels may be due to TBG (Thvroid Binding
Globulin) reduction.
The failure to detect a difference in serum TSH values in this study
indicates that the fall in T3 and T4 levels observed in RDS infants are
secondary tc the illness.
This conclusion 15contirmed by tile feet that RDS is not a significant
problem in infants with congenital hypothyroidism.
Also, previous studies found that only during the course of respiratory
distress sy ndroma the values of T3 and T~ were pro9ressive Iy reduce d.
Thus, it appears that low circulating T~and To!- levels result from RDS
and do not cause it.
The depression of TJ and L. levels in ADS infants may ba a defence
reaction of the body attempting to protect sick tissues from excessive
metabolic stimulation and increased oxygen consumption and to reduce
protein catebcllsrn,