الفهرس | Only 14 pages are availabe for public view |
Abstract F.M.F. is a disease of unknown origin, characterized by recurrent febrile paroxysms of painful;serosal inflammation that generally last several days and resolves without sequalae. Amyloid nephropathy is the most threatening complications of F.M.F. patients which usually manifested clinically by proteinuria. Microalbuminuria indicates abnormal passage of albumin through the glomerular filter and its prognostic value has established in different diseases. Our study has been done on 25 F.M.F. patients and 20 normal subjects as control group aiming to evaluate the presence or absence of microalbuminuria in F.M.F. patients which may detect early renal affection in these patients. To all of them the following have been done to exclude other conditions that may cause similar clinical picture or may cause microalbuminuria: (1) Full history taking. (2) Full clinical examination. (3) Laboratory investigations including: (i) Urine analysis. (ii) Complete blood picture & E.S.R. (iii) Fasting and post prandial blood sugar. (iv) Hepatic and renal function tests. (4) Electrocardiography (E.C.G) 82 (5) Plain X ray chest. (6) Abdomenal ultrasonography. For selected cases of F.M.F. and control groups the following have been done: - Albumin in 24 hours collection of urine. - Microalbuminuria in 24 hours collection of urine. In this study we found the following: - No rnicroalburninuria in all control group. - Microalbuminuria is pressent in 14 cases out of 25 (56%) and absent in 11 cases out of 25 (44%). - Microalbuminuria has no significant relation to the age, sex, body weight, body mass index, sample timing and duration of the disease. - There is significant relation between microalbuminuria and colchicine treatment. Thus from this study we can conclude that: (1) The presence of microalbuminuria in patients with F.M.F. may help in early detection of renal affection in these patients. (2) Microalbuminuria has no relation to the sex, age, bodyweight, body mass index, sample timing and duration of the disease. (3) Colchicine therapy significantly reduce the incidence of microalbuminuria and so may stop the progression of renal affection in patients with F.M.F. Recommendations (1) Regular follow up of patient of F.M.F. every year by testing the presence of absence of microalbuminuria is very important. 2) Early treatment by colchicine therapy is of great value in these patients. |