الفهرس 
Material and methodsOnly 14 pages are availabe for public view
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Abstract
This study was conducted on 48 neonates: 21 patients with neonatal septicemia and 21 control. The patient and control groups were each divided into 3 subgroups: full term neonates, premature, and small for gestational age (SGA)
subgroups.
The patient group consisted of 13 The mean ages of patient groups group, ±3.6 days in the preterm group
healthy group it was ±2, ±2.6 and ±2.1 day The mean gestational ages of the
weeks for full terms and ±34 weeks fo diseased SGA and ±38.7 weeks for healthy
In this study C1-150 test was done and control groups, to investigate the infection.
In our study there was no signi cant relationship between sex and CHSO activity level. But there was male predomi ance among sepsis group (62%).
The CHSO activity increased i the patient group (72.02 Wm)) in comparison to the control group (29. 8 Wm!), which means that infection activates the complement system by clas ical and alternative pathways rising the
CHSO activity.
CHSO activity level was statistic. Ily insignificant in correlation with bad maternal obstetric history: PROM was p -sent in 8 cases when the mean of CHSO was 76.15 U/ml. Maternal fever was ositive in 5 cases (28%) and 0450 was 68.91 U/ml and cesarean section was in 6 cases (28%) and the mean of CHSO was 73.17 U/ml.
62%) males and 8 (38%) females.
as as follow: ±6.I days in the full term
nd ±5.6 days in the SGA group. In the
in the three subgroups.
ealthy and septicaemic groups was ±39
preterms while it was ±37.9 weeks for
SGA.
to measure the CHSO activity of patients alue of CHSO test as an indicator of
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Clinical data present in patient groups was statistically insignificant in correlation with CI150 activity. They included poor suckling and sluggish moro in 15 cases (75%) each, umbilical sepsis in 12 cases (60%) and CHSO was72.72 u/ml, respiratory distress in 7 cases (33%) and CHSO was 69.47 u/ml, convulsion in 6 cases (28%) and CHSO was 74.75 u/ml, jaundice in 6 cases (28%) and CHSO was 94.67 ti/ml, and DIC and necrotizing enterocolitis was in 1 case (5%) each.
CHSO level in control group was less in premature group (18.09 U/ml) and approximately equal in full term and SGA groups (34.70 U/ml and 36.23 U/ml.) and this explained by: the CHSO activity correlated respectively significantly with gestational age more than weight and this may explain why premature babies are in high risk of sepsis than full term neonates and SGA babies. CHSO level difference in patient group of the three subgroups correlated statistically insignificant because the infection may alter the CHSO activity level.
Specificity of CHSO test was 90%, sensitivity was 61% positive predictive value was 80% and negative predictive value was 70%.
In conclusion, in our study CHSO level was lower in premature groups and elevated with infection, had significant correlation with gestational age and CRP and insignificant statistical value with maternal history nor clinical picture. CHso test is a good test for sepsis having a specific more than a sensitive value.
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Recommendations
1.Try to decrease the number of premature deliveries. If it occurs, take all precautions to prevent septicemia.
2.Use CHSO test instead of or in addition to CRP test to confirm and follow up septicetnic cases.
3.Continue research to develop new tests which more accurately confirm septicemia.