الفهرس | Only 14 pages are availabe for public view |
Abstract -89- SUMMARY AND CONCLUSIONS Preeclampsia is one of the major problems in obstetric. Many theories and etiological factors had been studied to elucidate the cause of preeclampsia. Recently evidence suggested that a circulating digoxin like immunoreactive substance DLIS may be an important factor in the pathophysiology of preeclampsia. Our study included 62 primigravidae, from the same socio-economic class, from 16 to 39 years old. Who were admitted in labour, primigravidae were subdivided into 3 groups : 1. Group I (Control group) it included 30 normotensive primigravidae. 2. Group II (Mild-preeclamptic group) it included 17 primigravidae with mild preeclampsia. 3. Group III (severe preeclamptic group) it included 15 primigravidae with severe preeclampsia. -90- All women in the three groups were subjected: 1) To complete examination of the neonate (foetal birth weight, Apgar score at 1 minute and 5 minutes and gestational age). 2) Urine analysis for albumin. 3) Blood investigation sera collected from mothers and the foetuses were tested for estimation of DLIS by an Enzyme-Linked Immuno-Sorbant-Assay technique (ELISA) at delivery. Our study showed that : 1- There was a significant increase of the mean serum concentration of maternal DLIS in cases with severe preeclampsia, compared to normal and mild preeclamptic groups. 2- A positive correlation was found between maternal DLIS and gestational age in normal group, but not in both preeclamptic groups. 3- Foetal concentration of DLIS did not differ significantly between the three groups. -91- 4- Foetal DLIS was signHicantly higher than the corresponding maternal concentration, in the three groups. 5- A negative correlation was found between foetal DLIS and infant birth weight. |