الفهرس 
PreeclampsiaOnly 14 pages are availabe for public view
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Abstract
Evidence has accumulated for a pathogenic model of preeclampsia whereby an immunologically mediated deficiency in the trophoblastic invasion of the placental bed spiral arterioles resulting in poorly perfused fetoplacental unit, which in turn secrets mediators into the maternal blood causing the multisystem pathological changes characteristic of preeclamptic disease. VEGF possesses many of the characteristics required for a candidate circulating factor to be one of these preeclamptic mediators.
VEGF is a glycosylated glycoprotein which has a vasodilator and vascular permeability inhancing effects, in addition to angiogenic and a potent endothelial cell mitogenic properties.
The aim of the work was to find out if the serum level of vascular endothelial growth factor shows changes before the onset of preeclampsia that could be used as predictor for preeclampsia. This nested Cohort study included (625) normal healthy primigravidae between (28-32) weeks gestation. Serum samples were collected from all women, then women were followed up for development of preeclampsia until (2) weeks after their deliveries. At the end of our follow up, we constructed three study groups out of the followed up women, as follows :