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Abstract
Free radicals are atoms or molecules which contain unpaired electrons in the outermost shell. Any free radical involving oxygen can be referred as reactive oxygen species. Oxidants are reactive oxygen species. The antioxidants are category of components to counter the effects of reactive oxygen species. Oxidative stress is a profound imbalance between oxidants and antioxidants. The aim of our study is to evaluate the oxidative stress in CRF by estimation a number of oxidative stress markers : LP, GSH-PX, SOD and vitamin E, in CRF, in addition to study the correlation between these markers and each of inflammation, anaemia and CVS complication. the study was carried out in pediatric dialysis unit and outpatient clinic of Kasar Alani children hospital. It included forty five patients and twenty healthy children taken as control. The patients are classified into 2 groups [Group A] for HD patients, [Group B] for conservative treatment patients and [Group C] represented the healthy children. All patients and controls were subjected to full history taking and clinical examination in addition to the investigations which included routine laboratory investigation: HB, HCV, Urea, Creatinine, Creatinine Clearance, Albumin and CRP. Also there were the investigations of the research including LP, GSH-PX, SOD and vitamin E. the study revealed that the LP which is a product of the lipid peroxidation is increased while the antioxidants are decreased in patient compared the controls and this is attributed to the increased free radicals with a consequent consumption of the antioxidants reflecting the increased oxidative stress