Search In this Thesis
   Search In this Thesis  
العنوان
Synthesis of Some New Modified Nucleosides and Glycosides As New Anti-Viral Agents /
المؤلف
Saad, Waleed Talaat Mokhtar.
هيئة الاعداد
باحث / Saad,Waleed Talaat Mokhtar
مشرف / Omar Makram Ali
مناقش / Omar Makram Ali
مناقش / Ibrahim F. Zeid
الموضوع
Therapeutic Chemistry.
تاريخ النشر
2003.
عدد الصفحات
68 p. ;
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
علوم المواد
تاريخ الإجازة
1/1/2003
مكان الإجازة
جامعة المنوفية - كلية العلوم - Chemistry
الفهرس
Only 14 pages are availabe for public view

from 89

from 89

Abstract

Glycoside synthesis as a very common reaction in nature providing a great variety of oligosaccharides and glycoconjugates as glycolipids, glycoproteins and glycopeptides. As recognized only recently, the structural diversity of the oligosaccharide portion, which is inherent in the variability in the glycoside and specificity. For this fact, the field of the synthetic carbohydrate chemistry grow up exponentially in the last twenty years in order to synthesize oligosaccharides for specific purposes which include their use in antibody production, screening of antibodies, lectin and selection specificity, interaction studies with virus1,2 and bacterial receptors3-5, substrates for glycosidases6,7 and glycosyltransferases8 and probes in molecular recognition studies including conformational analysis. To date, it is the challenge for the synthetic chemist to built up glycosidiclinkages with high region- and stereocontrol similar to the naturally occurring ones. Two different approaches are generally used for the O-glycoside bond formation:
- Enzymatic O-glycoside bond formation
- Chemical O-glycoside bond formation