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Abstract
Nephrotic syndrome is a common renal pediatric disorder and one of the commonest causes of secondary hyperlipidemia in children, with the risk of early development of atherosclerosis.
Adiponectin is an adipose-specific hormone of the collection family that have antiatherogenic and anti-inflammatory properties in contrast to other adipokines.
This work was carried out during the period from November 2005 to February 2007 and comprised 45 1ry nephrotic syndrome patient from the Pediatric Nephrology Clinic,Children’s Hospital, Ain Shams University and 45 healthy children as a control group.
The aim was to assess the state of adipoinectin in nephrotic syndrome .
Patients were subjected to full history, thorough clinical examination and laboratory assessment of adiponectin level, CBC, ESR, renal function and lipid profile.
Patient with nephrotic syndrome had higher adipoinectin level, compared to those in the control group and the difference was highly significant.
Patients with steroid resistant nephrotic syndrome had higher adiponectin level compared to steroid responsive patients and the difference was highly significant.
There was strong positive correlation between serum adiponectin levels and cholesterol, triglycerides, ESR and proteinuria whereas serum albumin had strong inverse correlation with adiponectin level.
In conclusion, serum adiponectin level was significantly higher in active primary nephrotic syndrome compared to those in remission and compared to healthy children, steroid resistant patients had higher level of adiponectin compared to steroid responsive patients.Adiponectin had strong positive correlation with cholesterol , triglycerides , proteinuria and ESR and it had strong inverse correlation with serum albumin .
This maybe a compensatory mechanism resulting mainly from proteinuria and plasma lipid abnormality in order to prevent the risk of early development of atherosclerosis and deterious effect of metabolic syndrome.