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Abstract
E.ndometrial carcinoma, that is a common tumour, develops most probably as an oestrogen-related tumour on top of atypical endomelrial hyperplasia. Inhibition of apoptosis may be a cause ol’ tumour iic\ elopment as it prolongs cellular life-span thus allowing accumulation of other genetic alterations. NF-kappaB is a transcription factor that may inhibit apoptosis thus may share in tumorigenesis. This study was based on 72 cases of endometrial biopsies that included normal cycling endometrium in the proliferative phase, hyperplastic and adenocareinomatous endometrium. There was a statistically significant difference among the different studied groups regarding the age in years. Also there was a statistically significant difference between malignant and non malignant groups regarding patients’ ages in years . There was a statistically significant difference between the studied groups regarding the mitotic index. Also on evaluating the differences between the malignant and non-malignant groups regarding the mitotic index, a statistically significant difference was detected. There was a significant relationship between the different tumor types and tumor grade. There was a significant relationship between tumor grade and myometrial invasion. There was a significant relationship between tumor grade and lymph node metastasis.Regarding tumor stage, a statistically significant difference among different tumor types studied was detected.