الفهرس يوجد فقط 14 صفحة متاحة للعرض العام
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المستخلص
The effect of epilepsy and antiepileptic drugs on the endocrine system had attracted the attention of investigators for many yeas. Patients with epilepsy often complain of symptoms that may be caused by disturbances in their hormonal balance.
The aim of this study was to evaluate the effect of epilepsy and AEDs on the physical growth of patient with idiopathic epilepsy, as well as on the GH status in those patients.
This study comprised 40 patients with idiopathic epilepsy recruited from the Pediatric Neurology Outpatient Clinic, Ain Shams University Hospitals in the period from May 2006 to October 2006. Twenty apparently healthy age and sex matched children were chosen to serve as a control group.
Patients were subjected to complete history taking with special stress on age, seizure type and onset, disease duration, drug therapy regimen and its duration, control of seizure on therapy and seizure severity. Then complete physical and neurological examinations were carried out with special emphasis on anthropometric measurement [weight, height, BMI, span, midarm circumference (MAC) and occipitofrontal circumference (OFC)] and staging of pubertal maturation by Tanner score.
Adequate volume of venous blood was withdrawn from each patient and control at least one week from the last seizure episode for determination of liver and kidney functions, complete blood picture and serum levels of GH before and after provocation with L-dopa.
The results of this study revealed that the mean % of the median height for age was significantly reduced in patients with epilepsy compared to the controls group. When comparing the height in the different pubertal subgroups, the pubertal patients were significantly shorter than their matched controls.
Though the mean % of the median weight for age was not significantly different, the body mass indices of the patients were significantly higher compared to controls, especially the pubertal patient compared to their matched control group and in patients on VPA therapy compared to those on CBZ.