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Abstract
The present study was designed to evaluate and compare the possible protective role of natural honey and 16,16 dimethyl prostaglandin E2 administration against changes induced by toxic and therapeutic doses of Acetyl Salicylic Acid (aspirin) on the structure of fundus of stomach of adult male albino rat.
The experiment was conducted on 45 adult male albino rats with average weight 200 grams. Animals were randomly divided into the following five groups.
Group I: Consisted of five rats which served as control group and received one ml distilled water daily by gastric tube for 1 month.
Group II : Included ten rats which were subdivided into two subgroups :
Subgroup IIa : included five rats which received a daily dose of 2.5 g/kg of natural honey by gastric tube for 1 month.
Subgroup IIb : included five rats which received a daily dose of 40 ?g/kg of 16,16 dimethyl prostaglandin E2 by gastric tube for 1 month.
Group III: Comprised ten rats which were subdivided into two subgroups:
Subgroup IIIa : comprised five rats which received a single toxic dose of ASA (270 mg/rat) by gastric tube
Subgroup IIIb : comprised five rats which received the maximum therapeutic dose of ASA (54 mg/rat) daily by gastric tube for 1 month
Croup IV: Included ten rats. They were further subdivided into two subgroups :
Subgroup IVa : included five rats which received first a single dose of 2.5 g/kg natural honey, followed thirty minutes later by 270 mg/rat ASA both by gastric tube.
Subgroup IVb : included five rats which received daily 2.5 g/kg natural honey, followed thirty minutes later by 54 mg/rat ASA for 1 month both by gastric tube.
Group V : Consisted of ten rats. They were subdivided