الفهرس يوجد فقط 14 صفحة متاحة للعرض العام
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المستخلص
Long-chain polyunsaturated fatty acids (PUFA) (arachidonic AA and docosahexaenoic acids DHA) are essential for optimum fetal growth and development (Boelsma et al., 2001).
Diabetes mellitus impairs the synthesis of both AA and DHA (Ghebremeskel et al., 2004 and Thomas et al.,2004).
This study was conducted on 30 infants of diabetic mothers (both prepregnancy- DM ’PPD’ n=17; 56.6% and Gestational DM ’GDM’ n=13; 43.3%) and 20 babies as control group in addition to their mothers, chosen from Obstetrics & Gynaecology Hospital, Ain Shams University during the period from December 2005 to July 2006.
Lipid profile components (cholesterol, triglycerides ’TG’, low density lipoproteins ’LDL’ and high density lipoproteins ’HDL’) as well as PUFA (AA, DHA and their precursors linoleic ’LA’ and alpha linolenic acids ’ALA’) were assessed in diabetic ’GDM and PPD’ and non diabetic mothers as well as in their babies.
As regards cholesterol and TG levels, no statistical difference was found between diabetic mothers (GDM and PPD) and non diabetic ones, and same results were found between infants of diabetic and non diabetic mothers.
HDL levels were found to be significantly lower in diabetic mothers (specially those with PPD) compared to non diabetic ones, whereas no significant difference was found between babies of the two groups.
LDL levels were elevated in mothers with GDM compared to non diabetic ones and in infants of diabetic mothers (PPD and GDM) compared to those of non diabetics.
Also, the current study revealed that diabetic mothers (GDM and PPD) and their babies had significantly higher levels of PUFA precursors LA and ALA, compared to non diabetics and their babies.
PUFA (AA and DHA) were found to be significantly lower in diabetic mothers (GDM and PPD) compared to non diabetic mothers,and same results were found in the babies of the two groups.