الفهرس | Only 14 pages are availabe for public view |
Abstract The histopathology of the liver is fundamental for the differential diagnosis between intra- and extra- hepatic causes of neonatal cholestasis. To the histopathologist, cholestasis means the appearance of bile within the elements of the liver and usually associated with secondary cell injury. Aim: The aim of this study is to evaluate the role of histopathology in the diagnosis of cholestatic neonatal liver disease. METHODS: The histological studies: Sections were evaluated as following: ? Cholestasis was graded as: Grade (1+), Grade (2+), and Grade (3+). ? Portal oedema was graded as: Grade (1+), Grade (2+), and Grade (3+). ? Proliferation of ducts graded as: Grade (1+), Grade (2+), and Grade (3+). ? Cholangitis: was graded as: Grade (1+), Grade (2+), and Grade (3+). ? Fibrosis was scored as follows: (0), (1+), (2 +), (3 +) and (4 +). Results: NH was found to be the commonest cause of neonatal cholestasis. Biliary atresia and neonatal hepatitis were diagnosed approximately in 82% of cholestatic cases during neonatal period. CONCLUSION: Portal tract changes were discriminatory variables between IHC and EHC. Features supporting the diagnosis of extra-hepatic cholestasis include portal fibrosis, portal oedema, proliferation of interlobular bile ducts, cholestasis in neoductules and cholangitis. Only extra-medullary hematopoiesis pointed to diagnosis of intra-hepatic cholestasis. |