الفهرس يوجد فقط 14 صفحة متاحة للعرض العام
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المستخلص
Idiopathic pulmonary fibrosis has been associated with impaired prognosis compared with other types of ILD, it is therefore important to rapidly asses the likelihood of a patient having IPF.
The aim of this work is to try to know if the study of bronchoalveolar lavage cellularity in suspected cases of ILD is helpful in differentiating various types of ILD, also to find out its relationship to the extent of disease on HRCT and the possibility that transbronchial lung biopsy is helpful in the establishment of final diagnosis.
All cases were subjected to full history taking, clinical examination, HRCT scan, FOB with BAL and transbronchial lung biopsy, BAL cellular analysis including CD4/CD8 ratio.
It was found that HRCT scanning of the chest has changed the diagnostic evaluation of patients with IPF.
There was a significant correlation between lymphocyte and diagnosis of various types of ILD (P-value 0.04), distribution of lesion (P-value 0.033), BAL lymphocytosis was highly suggestive of sarcoidosis and LIP. The likelihood for sarcoidosis rose with increasing CD4/CD8 ratio. Also there was a significant correlation between lymphocyte and extent of the disease on HRCT (P-value 0.04), BAL lymphocytosis in IPF cases has been associated with early pathological changes (Groundglass), less honeycombing.
In the group examined, study of bronchoalveolar lavage cellularity in suspected cases of ILD is helpful in narrowing the differential diagnostic possibilities between various types of ILD, and CD4/CD8 ratio was helpful in establishing the diagnosis of sarcoidosis. Broncholaveolar lavage cellular analysis also has a good correlation with extent of disease on HRCT. Transbronchial lung biopsy is helpful in the establishment of final diagnosis without need for open-lung biopsy.