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Abstract
Diabetes mellitus is a syndrome characterised by chronic hyperglycemia and disturbance of carbohydrate , protein and fat metabolism . Diabetic nephropathy is an important complication ofdiabetes preceded by a long silent phase characterized by subclinical increase in albumin excretion known as microalbuminuria. Monocyte chemoattractant protein-1(MCP-1)is one of the CC chemokine family .Chemokines represent a class of cytokines that have chemoattractant properties and subdivided into CC and CXC subfamilies . MCP-1 is secreted in response to a wide range of cytokines such as IL-6 and TNF-a by mononuclear cells and glomerular mesangial cells . MCP-1 exhibit its most potent chemotactic activity towards monocytes and T lymphocyte cells. The aim of the present work is to study the role of MCP-1 in development of diabetic nephropathy . This study was carried out on three groups : group I cosists of 10 healthy persons as controls , group II consists of 20 diabetic patients without nephropathy and group III consists of 20 diabetic patients with nephropathy . It was found that : serum MCP-1 was significantly elevated in diabetic patients with nephropathy when compared to diabetic patients without nephropathy and healthy controls , also serum MCP-1 was positively correlated with HbAlc and microalbuminuria . Conclusion : the present study supports the studies that persistent hyperglycemia in diabetic patients increase the production of MCP-l which plays an important role in the development of nephropathy.