الفهرس 
INTRODUCTION AND AIM OF THE WORKOnly 14 pages are availabe for public view
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Abstract
Vitiligo is a common, acquired, idiopathic patchy, macular, chronic depigmentary disorder which affects 0.14% to 3.0% of the world population,, It is gradually progressive over many years. All races and both sexes seem equally vulnerable to the disease.
There is a pronounced dominantly inherited predispo sition to the disease as indicated by a family history of the same problem.
The speculations concerning the aetiology of
vitiligo, as whether it is related to autoimmune neural and neurohormonal, se’lf destructive, combined hypothesis or otherwise was vigorously debated. There is a strong evidence that autoimmune mechanisms have been especially popular. The self destructive hypo thesis means failure of protection against toxic inter-mediates generated during melanogensis while neural and neurohormonal theory suggests that there is a neuroche-mical mediator that destroys or inhibits melanin produc-tion. ON the other hand, composite hypothesis proposed that both autocytotoxic and immune hypotheses can be combined into a single explanation for vitiligo.
Immunologically both humoral and cell mediated immunities are involved in the pathogenesis of vitiligo.