الفهرس 
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Abstract
The aim of the present investigation was to study the effect of oral sodium ortho-vanadate administration on fasting serum glucose, oral glucose tolerance test, KG value, fasting serum lipids, creatinine and urea clearancees and total kidney to body weight ratio.
Ninety-six male albino rats were utilized in this study. They were divided into two main groups : non-diabetic group and a diabetic group.
The first group was divided into two equal subgroups non-diabetic control group and vanadate-treated non-diabetic group.
The second group was divided into four equal subgroups alloxan-diabetic group, vanadate-treated diabetic group, insulin-treated diabetic group and combined vanadate and insulin-treated diabetic group. Diabetes mellitus was induced by intra-peritoneal injection of alloxan monohydrate solution- The first subgroup was served as diabetic control group. The second subgroup was given sodium ortho-vanadate orally. The third subgroup was treated with subcutaneous insulin daily. The last one, was treated by both sodium ortho-vanadate and insulin simultaneously.
Rats in each group, were divided into two divisions. The first division of rats was used for taking blood samples for performance of oral glucose tolerance test, calculation of KG value and estimation of fasting serum lipids. The second division of rats was used for performing creatinine and urea clearances and calculation of total kidney to body weight ratio.
Sodium ortho-vanadate administration in normal control rats didn’t affect any of the previously mentioned parameters when compared with the corresponding values in non-diabetic control group.