الفهرس 
Review of LiteratureOnly 14 pages are availabe for public view
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Abstract
Sixty-six urinary bladder specimens from Egyptian patients were studied. They composed of 57 bladder carcinoma and 9 cystitis lesions as a control group. Histopathologic examination of 57 bladder specirnens revealed 35 (61.4 %) TCC, 10 (17.5 %) SCC, 5 (8.8 %) adenocarcinoma, 5 (8.8 %) undifferentiated carcinoma and 2 (3.5 %) carcinoid tumor. Associated schistosomiasis was found at 33.3 % of cystitis lesions and 40.4 % of bladder carcinomas. Of the 57 bladder carcinoma cases studies, there were 48 males and 9 females with MIF ratio of 5.3:1. Their ages ranged from 35 to 76 years with a mean ± SD of 57.12 ± 9.49.Flow cytornetric DNA measurements in fresh frozen urinary bladder specimens and TGF-f31 immunocytochemistry for formalin fixed, paraffin embedded bladder biopsy for the same lesions were carried out.
All cystitis lesions express DNA ploidy pattern but only 42.1 % of malignant cases showed this pattern. A high SPF 10 % was seen in two cystitis lesions that were schistosomal cystitis with squamous metaplasia of urothelium.
In this study, flow cytometric DNA measurements showed a statistical significant difference regarding low and high grade and also low and high pathologic stage carcinomas. Low grade urothelial carcinoma (grade 11, TCC) constituted a heterogeneous group may be subdivided into 2 subgroups with diifrent outcomes on the basis ol’ flow cytometric characteristics.