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Abstract • Preterm labor is defined as spontaneous onset of labor occurring before completed 37 weeks of gestation. It varies between 5-15% of the number of live birth and increase much more in developing countries. • The aim of this work is to assess the efficacy of cyclo-oxygenos-2 inhibitors (celecoxib) in arresting preterm labor and to evaluate its value in prolongation of gestation compared to ritodrine. • In this work we have conduct an observational study comparing oral Anticox-2 to oral ritodrine 30 pregnant women diagnosed as preterm labor with gestational age ranged between 24-34 weeks we randomly classified into two groups. • First group: consists of 15 pregnant women with preterm labor pain in which oral celecoxib was given after hydration. • Second group: consists of 15 pregnant women in which oral ritadrine was given after hydration. • The result was analyzed and end results were: 1- There were no significant difference in the demographic data in the two groups before the use of any treatment. 2- No significant difference between the two groups as regard the successful response to initial therapy. 3- Ritodrine group shows more days of prolongation then celecoxib, but with no statistical differences. |