الفهرس 
FibronectinOnly 14 pages are availabe for public view
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Abstract
Fibronectin, a family of structurally and immunologically related high molecular weight glycoprotein, exists on many cell surfaces, connective tissues, most basement membranes in insoluble form and in extrecellular fluids, and in plasma in soluble form. It is produced by fibroblasts, astroglial cells, Schwann cells, endothelial cells, chondrocytes, myoblasts, certain epithelial cells, and alpha-granules of platelets.
A variety of functions have been ascribed to fibronectin, including roles in opsonizati n, cell adhesion, cell motility, tissue repair, coagulation, regulating cellular functions and an important role in the proliferation of trophoblastic cells and tissue organization of the placenta.
The levels of normally circulating fibronectin is 200-400 ug/mi and are thought to result primarily from synthesis by the vascular endothelium. Patients with less than 5% of normal concentration of fibronectin, have higher mortality than patients with normal concentration. Fibronectin deficiency has been documented in various clinical states including trauma, surgery, burn, sepsis, disseminated intravascular coagulation.