الفهرس 
Suppression of chemokine responses
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Abstract
The generation of an inflammatory response is a critical mechanism through which mammalian species respond to and protect themselves from infectious as well as non-infectious insults (299). In terms of the lung, both non specific and antigen specific (immune) mechanisms may lead to an inflammatory response. While this response is usually protective and beneficial, inflammation also has the potential to injure tissues, including the airways, within the lung (280).The inflammatory process in the bronchial tree and lung parenchyma is complex. It involves the release of many mediators including chemoattractants, and cytokines that regulate the adhesion molecules, the process of cell migration, and their activation and degranulation (272).The production of proinflammatory cytokines by airway epithelium and blood leukocytes has been of particular interest in both allergic conditions such as asthma and allergic rhinitis and non allergic airway conditions such as COPD and lung cancer. This has been studied widely because these compounds influence the activity of inflammatory cells such as eosinophils, neutrophils, T lymphocytes and mast cells, which are the characteristic infiltrating cells in these disorders (126, 169, 261).
Several studies have demonstrated the importance of assessment of these inflammatory mediators and their reeptors both in serum and BAL and their relevance to the pathogenic processes underlying many diseases(300, 301).Of these cytokines, IL-8 has been subjected to intense research because of its potent neutrophil chemoattractant activity and it has been of particular interest in studies investigating the pathogenesis of COPD 168).