الفهرس 
REVIEW OF LITERATUROnly 14 pages are availabe for public view
 |  | from | 208 |  |  |
| | | from | 208 | | |
Abstract
Ketorolac tromethamine is a non-steroidal, anti- inflammatory analgesic indicated for the relief of moderate to severe pain. Its pronounced analgesic efficacy is comparable to that of the opioid analgesics without some of their adverse effects. The analgesic1 anti -inflammatory and antipyretic properties of Ketorolac are mediated through its potential to inhibit prostaglandin, prostacyclin and thromboxane formation due to its inhibitory action on cyclo-oxygenase enzyme in the arachidonic acid pathway.
Ketorolac is rapidly and completely absorbed following oral, intramuscular or intravenous administration and has rapid onset of action. Furthermore, its analgesic effects are long lasting. Clinical studies in patients with moderate to severe pain, following different surgical procedures and some medical conditions, have demonstrated that ketorolac is effective as opioid analgesics without oploid drawbacks. In very severe pain, ketorolac may be combined with opioids. This allows lower dose of the opioid to be used.
In comparison with opioid analgesics, ketorolac displays good tolerability. It dose not depress respiration. There is no risk of abuse or physical dependence and there are no signs or symptoms of withdrawal following cessation of treatment, although this does not happen with oploids if used for short time to control post-operative pain.
Clinical evaluation of ketorolac was carried out in the postoperative period to detect the efficiency of this drug as regards its