الفهرس 
REVIEW OF LITERATUREOnly 14 pages are availabe for public view
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Abstract
In neuropathic pain, no one mechanism may be diseaseeific and each disorder may have several mechanisms typically
.Dciated with it. Accounting for the pain in any single patient may
hypothesising one or more mechanisms at work
itaneously. Therefore, a patient with post-herpetic neuralgia
share an underlying pain mechanism with a diabetic neuropathy
yet may have pain mechanisms distinct from those of other
nts with post-herprtic neuralgia. This heterogeneity may
r!2 only a subset of patients within each diagnostic category
ds to a particular drug.
Due to the recent explosive growth in our understanding of the cu1ar. cellular and systems mechanisms responsible for ciception and pain, we should focus on the need for a mechanism
classification of pain. A mechanism-based classification of could have profound implications: drugs may be developed
target distinct mechanisms and we may have more reliable
valid tools for treatment and clinical investigation.
Epidural administration of drugs is followed by a considerable
of the drug being absorbed to the CSF and readily available
act directly on the dorsal horn of the spinal cord where
:z::sing and modulation of the pain signal takes place. Therefore,
ral testing of the efficacy of mechanism-target drug may be a
tool in identifying neuropathic pain mechanism(s) for
ividual patients, on the light of the responsiveness to the injected