الفهرس 
REVIEW OF LITERATUREOnly 14 pages are availabe for public view
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Abstract
Carcinoma of the breast is a major public health problem. It is one
of the leading causes of cancer death among women all over the world,
with about one million new breast cancer cases diagnosed per year (Zhao
et al, 2004).
This study was conducted on 75 subjects of whom 25 were normal
healthy female controls and 50 were patients undergoing surgery for
breast cancer (preoperative).
The age range of the breast cancer and control groups was the same
(50-65 years), although it is found that age has no effect on serum VEGF
and serum IL-6 levels i.e. it dose not influence their expression.
This study was performed in order to evaluate the diagnostic
significance of serum VEGF and serum IL-6 levels in breast cancer in
comparison to serum CA15-3 levels and histopathological study.
All patients were examined clinically after taking their clinical past
history then the following investigations were done for each patient:-
Serum levels of VEGF.
Serum levels of IL-6.
Serum levels of CA15-3.
The results were tabulated and statistically analysed, we found that:
The serum levels of VEGF, IL-6 and CA15-3 in breast cancer
group are significantly elevated compared with those of the controls.
Serum IL-6 and serum CA15-3 levels are significantly elevated in
metastatic group compared to the non L.N. metastasis group, while serum
VEGF shows a non significant difference.