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Abstract The infusion of hypertonic saline has been reported to be effective in the treatment of hypovolemia in experimental and patients studies. Hypertonic saline 7.5% (2400 mosm/L) has been shown to improve the hemodynamic state after hemorrhagic shock, leading to high survival rate even when given in small volumes (approximately 4ml/kg) and as a sole treatment. These benificial effects are attributed to the increase in myocardial contractility, widespread precapillary dilation, fluid redistribution and neurogenic, cardiovascular reflex originated in the lungs. There is marked increase on plasma volume also there is improvement in acid - base balance. The addition hyperoncotic 6% dextran 70 to the hypertonic saline solution improves effectiveness of the resuscitation from hemorrhagic shock. |