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Abstract Cardiopulmonary bypass (CPB) produces many alterations in endocrine homeostasis, which may exert substantial hemodynamic effects postoperatively. A series of articles starting in 1975s heralded the clinical investigations of hormonal responses to CPB and continuing till the present time .Transient decrease in left ventricular function in the immediate postoperative period have been reported in patients with normal preoperative ejection fraction, as well as in patients with impaired ventricular function. The cause of this transient ventricular derangement is usually attributed to either inadequate intraoperative myocardial protection or reperfusion injury . Alterations in thyroid hormones metabolism may contribute to cardiac dysfunction after open heart surgery. It seems likely that a depressed thyroid state at the end of the operation might contribute to left ventricular dysfunction. However, after CPB some patients have low cardiac output, responding poorly to conventional inotropic stimulation . |