الفهرس 
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Abstract
Griseofulvin has been widely used in the treatment of different types of fungal infection (tinea) in man and animals . The aim of the present work was to study some histological and histochemical changes occurring in the liver following administration of griseofulvin. Material and methods: In the present work, 48 adult male albino rats were used. They were divided into two main groups: I- The control group : which was subdivided into : - Negative control (included 8 rats) : for studying the norrnal histological and histochemical structure of the liver . - Sham control (included 16 rats) : which were given distilled water daily via an oesophageal tube using the same doses and periods of experimental group. 11- The experimental group: which was divided into two main groups: I - Group A (included 12 rats) : was given griseofulvin orally (dissolved in distilled water) using an oesophageal tube in a mean therapeutic dose of 18 mg daily for different periods. 2- Group B (included 12 rats) : was given double the therapeutic dose of griseofulvin (36 mg daily) for different periods.