الفهرس 
SerotoninOnly 14 pages are availabe for public view
 |  | from | 121 |  |  |
| | | from | 121 | | |
Abstract
In this study the serotonin level i n the brain of normal r a b b i t s ranged from 245 t o 270 nanogram/gm wet t i s s u e with a mean value of 259.666 2 1.98 nanogram/gm wet tissue. After administration of the druga ( chloroquine or primquine ) by e i t h e r the intravenous or the oral route there, was s i g n i f i c a n t lowering of the 5-RT content of the brain and kidney as shown from the following r e s u l t s : I. After 1.V administration of chloroquine i n a dose of 50 mg /Kg body weight 5-HT l e v e l decreased t o values between 150 - 190 nanogram/ gm wet brain t i s s u e with a mean value of 161 . 666 -+ 2,954 nanogram/ g m wet t i s s u e . After 1.V. administration of primaquine i n a dose of 0.75 mg/Kg body weight 5-HT level decreased to values between 150 - 190 - nanogram / gm wet brain t i s s u e with a mean value of 171 . 333 + 3.065 nanogrem/ gm wet t i s s u e , After o r a l administration of chloroquine i n a dose of 50 mg/Kg body weight 5-HT l e v e l decreased t o values between 235 - 265 nanogram/ gm wet brain t i s s u e wi t h a mean value of 2#9 .00 -+ 2.1 99nanogram/gm wet t i s s u e , 4F After o r a l administration of primz>quine i n a dose of 0.75 mg/Kg body weight 5-HT l e v e l decreased t o values between 230 - 270 nanogram/ gm wet brain t i s s u e with a mean value of 252 .333 & 2.881 nanogram/gm wet t i s s u e , 5. After in&avenoua administration of chloroquine i n a dose of ..50 m&/Kg body weight the serotonin content varies between 22 : 30 nanogram/ gm wet kidney tisaue with a mean value’ of 25.0 2 0.4879 . nanogram/gm wet kidney tissues. 6. After intravenous administration of primaquine i n a dose of 0.75 %/Kg body weight the serotonin content varies between 25 : 32 nanogram/gm w e t kidney t i s s u e s with a mean value of 28.0 + 0.569 . 7. After oral administration of chloroquine i n a dose of 50 mg& body weight 5-HT l e v e l varies between 2C-38 nanogram /gm wet kidney t i s s u e with a mean value of 32.133 2 0.755 nanogram/gm wet t i s s u e , 8. After o r a l administration of primaquine i n a dose o f 0.75 mg/Kg body weight 5-HT l e v e l varies between 28- 36 nanogram /gm wet kidney t i s s u e with a mean value of 32.333 -+ 0.7346 nanograrn/gm wet t i s s u e .