الفهرس 
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Abstract
The thesis comprises of three main chapters are concerned with preparation and characterization of some new transition metal complexes with chelating agents contain variety of donors; i.e, NNS (thiosemicarbazones derived from pyridine-2-carbaldehdye and 6-methylpyridine-2-carbaldehdye), O,O (2-hydroxy-1-napthoic acid), NSO (6-amino-4-hydroxy-2-thiopyrimidine) and ONO (Schiff-bases derived from 4-hydroxysalicyladehyde and potassium salt of glycin or anthranilic acid). The examination of some of these ligands and some of their complexes as anticancer agents against human colon cancer (HCT116) and breast cancer (MDA-MB231) cell lines is reported on the bases of their structures. Chapter 1: Introduction This part is concerned with literature survey on the chemistry of transition metal complexes with variety of chelating agents, i.e: thiosemicarbazones, hydroxycarboxylic acids, pyrimidines and thiopyrimidines, and Schiff bases derived from 4-hydroxysalicylidine and amino acids. Moreover, literature survey on the biological activities of the some related complexes as anticancer agents. Chapter 2: Results and Discussion characterization of the prepared compounds on the basis of elemental analysis, spectral techniques (X-ray crystallography, IR, Raman, 1H, 13C ,31P NMR, UV-vis and mass), molar conductance and thermal measurements. -The examination of the anti-cancer activity of thiosemicarbazone and their Zn(II) and Pd(II) complexes against human colon cancer HCT116. 6-amino-4-hydroxy-2-thiopyrimidine(Hahtp) and its Zn(II), Pd(II) and Ag(I) complexes against MDA-MB231 breast cancer cells. The obtained data has revealed that [Ag(ahtp)(PPh3)(H2O)] is the most active complex against MDA-MB231 breast cancer cells. Chapter 3: Experimental This part consists of preparation methods of the ligands and their complexes. Also, includes the materials, instruments and tools applied in this thesis.