الفهرس 
Introduction & aim of the workOnly 14 pages are availabe for public view
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Abstract
Nephropathy is one of the most serious microvascular complications of diabetes. It is characterized by increased urinary albumin excretion (UAE), an increase in blood pressure, a progressive decline in glomerular filtration rate and eventually resulting in end-stage renal disease (ESRD). Nephropathy, in particularly, in type 2 diabetes has become a medical problem in the last few years worldwide. Many factors are involved in pathogenesis of diabetic nephropathy, including haemodynamic, metabolic and genetic factors. One of the candidate genes that may be associated with diabetic nephropathy in type 2 diabetes mellitus is the insertion/deletion (I/D) polymorphism in intron 16 of the angiotensin converting enzyme (ACE) gene. The present study was carried out to explore whether ACE gene polymorphism is a determinal factor in causation and progression of chronic renal failure among Egyptian patients with type 2 diabetes, with particular focus on the role of a number of related biochemical parameters in this context. This study concluded that diabetic patients with nephropathy were older, more obese and had higher systolic and diastolic blood pressure (SBP and DSP), blood glucose and lipid profile in both sexes. While, the distribution of genotypes or allelic frequencies for all the studied gene polymorphisms did not differ significantly between controls and diabetic patients (with or without nephropathy). Also, no significant differences were displayed between diabetic patients with micro and macro-albuminuria. So, a role for ACE gene polymorphism, as a genetic marker in initiation and development of nephropathy in the studied sample of the Egyptian patients with type 2 diabetes can not be considered.