الفهرس 
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Abstract
Objective: to study the histological and the ultrasturctural changes in the testes of the adult male albino rats after neonatal estrogen exposure. Materials and methods: the male pups of forty pregnant female albino rats were divided into three equal groups: group I: control group, group II: male pups that were injected by low dose of estrogen, group III: male pups that were injected by high dose of estrogen. One testis, from each animal, was fixed in Bouin’s fixative and processed to obtain 5 μm thick paraffin sections for histological study. For electron microscopic study, perfusion was done , then the testes were trimmed to obtain very small fragments to be processed for examination by transmission electron microscope. Results: On histological examination in low dose group (II): The majority of the tubules exhibited a normal histological appearance, yet some of them, showed structural variations. Some tubules revealed absence of spermatogenic series on some areas and preserved series at others . Some tubules showed spaces in between the spermatogenic cells. In high dose group (III): Examination of the testes revealed that several tubules showed decrease in the thickness of the seminiferous epithelium. In some tubules, there was complete arrest of spermatogenesis and, only spermatogonia were lying on the basement membrane. The degenerated tubule showed few sperms attached to the Sertoli cells and in the lumen. Conclusion: from the present study we concluded that neonatal estrogen exposure of male albino rat leads to major histological abnormalities in their testes which will persist until adulthood interfering with the normal functions of the testis and thereafter sperm production.