الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Background: Bronchial asthma is a chronic inflammatory disease of the airways, characterized by bronchial hyper responsiveness and obstruction.Asthma is one of the most common diseases encountered in clinical medicine, in both children and adults. Accumulating evidence suggests that environmental factors associated with allergic sensitization and exposure to microbial stimuli during infancy and early childhood, are associated with these changes in prevalence. Aim of Work: The present study represents a way to explore the pathology of asthma and also provides an idea about the base for its treatment. Patients and methods: Forty adult guinea pigs ranging in weight from 300-400 grams were used in this study and were classified into 4 equal group : Group A: animals served as control. Group B: animals were sensitized (injected intraperitoneally with 1ml/350gm of 10% ovalbumin) weekly for 6 weeks. Group C: animals after induction of bronchial asthma as in group B were given corticosteroid therapy; oral Prednisolone in a dose of 5mg/kg once daily for 6 weeks by means of gastric tubes. Group D: animals after induction of bronchial asthma as in group B were given leukotriene receptor antagonist therapy; oral Montelukast in a dose of 10 mg/kg once daily for 6 weeks by means of gastric tubes. Bronchi and lung tissue of each guinea pig was obtained and processed for light and electron microscopic studies. Results: From that point we conduct our study on 40 guinea pigs divided into 4 groups examined by light and electron microscope which revealed: Haematoxylin and Eosin stained sections of asthmatic group showed increased goblet cells, submucosal inflammatory cell infiltrate and epithelial damage. In group treated with corticosteroid therapy it showed restored epithelial tissue with diminished inflammatory cell infiltrate. Group treated with leukotriene receptor antagonist showed minimal improvement in asthmatic changes.After induction of bronchial asthma, fibrous tissue was seen in sections stained with Mallory trichrome stain. Subepithelial collagen fibres deposition was noted to diminish after corticosteroid therapy more than in group treated with anti-inflammatory drug therapy.These changes diminished with corticosteroid therapy more effectively than anti-inflammatory drug therapy. Transmission electron microscopic study in asthmatic group exhibited ciliary loss in most epithelial cells with distorted tight junctions between cells. Scanning electron microscopic study in asthmatic cases showed ciliary disruption and increased goblet and mucous secreting cells with the presence of mucous film over it. Conclusions: From the present study we concluded that bronchial asthma includes major hisopathologic changes in bronchial tree. Most of these changes was effectively treated with corticosteroid drug therapy more than leukotriene receptor antagonist drug therapy.