الفهرس 
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Abstract
Vitamin A acts on vertebrate organisms during odontogenesis and pre- and post- birth cellular differentiation process, reproduction, normal growth, maintenance of visual function, regulation and proliferation of tissue epithelial structures. Isotretinoin (13-cis retinoic acid), a derivative of vitamin A, has been used to treat severe cystic or recalcitrant acne vulgaris along with all the systemic retinoids, has been found to be a potent teratogen. Historically, it has been recorded that Nigella Sativa (N.S.) seeds were prescribed by ancient Egyptian and Greek physician to treat headache, nasal congestion, toothache and intestinal worms as well as diuretic to promote menstruation and increase milk production. This study aimed to evaluate the effect of isotretinoin and N.S. on tooth development in Albino rat offspring. The results showed that the tooth germ of the 1st molar was delayed in its development compared to other groups. In conclusion isotretinoin was shown to be toxic causing retardation of tooth germs development.