الفهرس 
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Abstract
The work presented in this thesis is aiming at designing and synthesizing novel polycyclic compounds containing the benzofuran and/ or furochromone scaffolds in their molecules as well as evaluating their biological impacts, particularly as antitumor agents. As starting materials, 4-methoxy-5-acetyl-6-hydroxybenzofuran and 4,7-dimethoxy-5-acetyl-6-hydoxybenzofuran were used. Compounds and ) are essentially prepared via alkali hydrolysis of the naturally occurring furochromones, namely Visnagin and Khellin , respectively. The - pyrone ring is cleaved upon reaction with pyrrolidine in boiling ethanol to give the respective enaminoketones and which are also used as suitable synthones in the present study . The antitumor activities of certain selected new products were screened, in vitro, against a panel of four (breast: MCF-7, cervix: HELA, colon: HCT116 and liver: HEPG2) human solid tumor cell lines and the structure-activity relationship (SAR) was discussed. The most promising result against (MCF-7) was recorded by the Selenium-containing compound