Search In this Thesis
   Search In this Thesis  
العنوان
Therapeutic central nervous system stimulants :
المؤلف
Moustafa, Samar Saad EL-Sayed.
هيئة الاعداد
باحث / سمر سعد السيد مصطفى
مشرف / محمد إبراھيم ولاش
مشرف / ناھد محمود العنانى
مناقش / محى محمد خالد شرف
مناقش / فوزى على إسماعيل
الموضوع
Neurophysiology. Nervous system - Anatomy.
تاريخ النشر
2010.
عدد الصفحات
242 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
Analytical Chemistry
تاريخ الإجازة
1/1/2010
مكان الإجازة
جامعة المنصورة - كلية الصيدلة - الكيمياء التحليلية
الفهرس
Only 14 pages are availabe for public view

from 277

from 277

Abstract

The present thesis is devoted for developing new methods for the analysis of certain central nervous system stimulant compounds, namely: ephedrine HCl, phenylpropanolamine HCl and pseudoephedrine HCl, either in pure forms or in pharmaceutical preparations. A sensitive spectrophotometric method was proposed for the determination of ephedrine HCl, phenylpropanolamine HCl and pseudoephedrine HCl, based on utilizing 2, 4 dinitrofluorobenzene reagent. A simple spectrofluorimetric method for the determination of ephedrine HCl, phenylpropanolamine HCl was accomplished, depending on oxidation with Ce (IV) ions. The method was successfully applied for the determination of ephedrine HCl, phenylpropanolamine HCl in tablet and ampoule formulations. Ephedrine HCl and phenylpropanolamine HCl were also determined by a spectrophotometric method by the use of Ce (IV) and p-dimethylamino benzaldehyde reagents. The method was applied for the determination of both drugs in tablet and ampoule dosage forms. A spectrophotometric charge transfer method was applied for the determination of phenylpropanolamine HCl using 2, 3, 5, 6 tetrachloro-1, 4-benzoquinone and acetaldehyde reagents. The method was applied for the determination of phenylpropanolamine HCl in tablet as well as in capsule and syrup dosage forms.