الفهرس 
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Abstract
The aim of the work is to design and synthesize new 5-aminoisoxazole derivatives which incorporate heterocyclic moieties of biological value (such as pyridine, quinoline, pyrazole, oxazole, quinclidine, pyrrole, pyrimidine). On the other hand, it seemed of significance to undertake the double Mannich reaction of 5-amino-3-methyl-isoxazole (1) as a bifunctional nucleophile for the synthesis of isoxazolo[5,4-b]pyrimidine and also introduce a basic nitrogen side chain into isoxazole moiety via Michael addition to aldimine or ketimine. Then, annulation of these compounds was affected by aromatic aldehydes to the corresponding isoxazolo[5,4-b]pyrimidine, also, the synthesis of dispiropyrrolidine was accomplished. Development of a new direct and simple entry into the isoxazolo[3,4-b]pyridine ring system via Mannich bases hydrochlorides. Preparation the azo compound of 1 with different diazonium salts. Preparation of 2(3-methylisoxazo-5-ylimino)thiazolidin-4-ones, and their condensation with aromatic aldehydes. Eventually, the displacement reaction of 2-chloro-N-(3-methylisoxazol-yl)acetamide with different amino compounds. Also, the displacement reaction of 1 with different halo compounds.