الفهرس 
Introduction and Aim of WorkOnly 14 pages are availabe for public view
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Abstract
Obesity is a serious universal health problem. It is associated with higher risk of insulin resistance, diabetes, hypertension, dyslipidemia, and cardiovascular disease. In addition, it’s a proven risk factor for Alzheimer’s disease, the most common form of dementia. The ketogenic diet is a high-fat, low-carbohydrate diet that has long been used to treat epilepsy, and is being considered as a potential treatment against neurodegenerative diseases. The diet also mimics aspects of starvation by forcing the body to burn fats rather than carbohydrates, therefore causing weight loss. The Mediterranean diet is associated with lower risk of cardiovascular disease and dementia. It’s a dietary pattern characterized by low consumption of red meat and high consumption of fruits, vegetables, and olive oil. Rimonabant is a cannabinoid 1 receptor blocker that has been shown to induce weight loss, improve dyslipidemia and hyperglycemia associated with obesity. br The present work aimed mainly to: br 1) explore the metabolic and neurodegenerative effects of obesity. br 2) examine the effects of dietary regimen with ketogenic and Mediterranean diets and rimonabant on obesity, its metabolic effects and relationship with neurodegeneration. br The effect of obesity and different dietary treatments and approaches were studied. The biochemical parameters were: br 1-Serum: glucose, fructosamine, insulin, total cholesterol, triacylglycerol, high density lipoprotein, tumor necrosis factor alpha and beta-hydroxybutyrate. br 2-Adipose tissue: adiponectin expression. br 3-Brain: APP, apoE and caspase-3 expression, total cholesterol, lipid peroxide and glutathione. br Histopathological study was performed on brain samples using the following stains: br 1- Hematoxylin and eosin stain to examine the effect of obesity and different treatments on cellular changes. br 2- Immunostain for bcl-2 protein to examine the effect of obesity and different treatments on the anti-apoptotic protein.