الفهرس 
AIM OF STUDYOnly 14 pages are availabe for public view
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Abstract
The thesis contains three parts, all of which concerned with the new transition metal complexes of 3-aminopyrazine-2-carboxylic acid (Hapc). Part I: Introduction This part is dealing with cancer, carcinogenesis, causes of cancer and cancer treatment. The anticancer activity of some transition metal complexes against different types of cancers have been also reported with their limitations due to their side effects. A brief knowledge about carboxylato and amino azine, diazines derivatives and their complexes were reported. Moreover, the catalytic activity of azine and diazine complexes as catalysts for epoxidation of olefins in presence of molecular oxygen and H2O2 were reported. Part II: Results and Discussion This part is concerned with the characterization of the isolated complexes by a variety of physical and chemical techniques including Raman, IR, electronic, 1H NMR, mass and ESR spectra, magnetic, conductometric, pH-metric and thermal measurements. Applications - Catalytic epoxidation of olefins: this section is dealing with the catalytic oxidation of a variety of olefins to the corresponding epoxides by [Ru(apc)2(H2O)2], [Ru(PPh3)2(apc)2] and [Ru(AsPh3)2(apc)2] in the presence of molecular oxygen as co-oxidant at 368 K under heterogeneous catalysis. - Anticancer activity: The target of this study is to find an effective drug against cancer without effects on the hematological and biochemical parameters. The complexes, cis-[Mo2O5(apc)2], [Pd(bpy)(apc)]Cl and [Pt(bpy)(apc)]Cl, show efficacy against cancer manifested by survival, activity and reduction in the tumour size. Part III: Experimental This part is concerning with the preparation of the new 3-aminopyrazine-2-carboxylic acid complexes; cis-[Mo2O5(apc)2], cis-[WO2(apc)2], trans-[UO2(apc)2], [Ru(apc)2(H2O)2, [Rh(apc)3], [Ru(AsPh3)2(apc)2], [Ru(PPh3)2(apc)2], [Rh(PPh3)2(apc)2]ClO4, [M(apc)2], [M(PPh3)2(apc)]Cl, [M(bpy)(apc)]Cl (M = Pd, Pt), [Pd(bpy)(apc)Cl], [Pd(phen)(apc)Cl], [Pt(phen)(apc)]Cl, [Ag(apc)(H2O)2], [Ag(PPh3)2(apc)].H2O, [Ag(bpy)(apc)], [VO(apc)2], [Ir(Hapc)2(H2O)2]Cl3 and [Ir(bpy)(Hapc)2]Cl3. The experimental details of the pH-metric measurements, catalytic epoxidation of olefins and the anticancer activity of some of the reported complexes against Ehrlich ascites tumour cells (EAC) in albino mice were recorded.