الفهرس 
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Abstract
The results of the present study could be summarized in the following points. The neuromuscular blocking agents are used as an adjunct to anesthesia to induce paralysis,so that surgery,especially intra-abdominal and intra-thoracic surgeries,can be carried out with fewer complications.Because neuromuscular block may paralyze muscles required for breathing, mechanical ventilation should be available to maintain adequate respiration.Hence, general anesthetics and analgesics must be given to prevent anesthesia awareness. The neuromuscular blocking agents are drugs that block the neuromuscular transmission at the neuromuscular junction, causing paralysis of the affected skeletal muscles.The mechanism of these drugs either by acting presynaptically via the inhibition of acetylcholine (ACh) synthesis or release, or by acting postsynaptically at the acetylcholine receptor. Succinylcholine(Suxamethonium) is the depolarizing blocking drug.It is the only such drug used clinically. It has a rapid onset (30 seconds) but very short duration of action (5-10 minutes) because of hydrolysis by various cholinesterases (such as butyrylcholinesterase in the blood). Succinylcholine was originally known as diacetylcholine because structurally it is composed of two acetylcholine molecules joined with a methyl group. The main difference is in the reversal of these two types of neuromuscular-blocking drugs that non-depolarizing blockers are reversed by acetylcholinesterase inhibitor drugs since they are competitive antagonists at the ACh receptor so can be reversed by increases in ACh.While,The depolarizing blockers already have ACh-like actions, so these agents will have prolonged effect under the influence of acetylcholinesterase inhibitors. The administration of depolarizing blockers will initially exhibit fasciculations (a sudden twitch just before paralysis occurs). This is due to the depolarization of the muscle. Also, post-operative pain is associated with depolarizing blockers.