الفهرس 
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Abstract
Cisplatin (CDDP) is a highly effective antineoplastic drug used for treatment of a wide variety of solid tumours (Lebwohl and Canetta, 1998 and Giaccone, 2000). However, nephrotoxicity is the major adverse effect represented by injury to the kidney cells (Lebwohl and Canetta, 1998). Ginger, the rhizome of Zingiber officinale, is a common condiment for various foods and beverages. Ginger also has a long history in the medicinal use dating back to 2500 years. The present work was conducted to study the nephroprotective effect of the aqueous extract of ginger on biochemical, histopathological, histochemical, ultrastructural and immunohistochemical changes induced by cisplatin in the kidneys of male albino rats. In this study, animals were divided into four groups: a)- Control group Animals were interperitoneally injected with normal saline (0.9) (the vehicle) for three consecutive days. b)- Ginger-treated group Each animal of this group was orally received 1ml of the final ginger aqueous extract every other day for a month. c)- Cisplatin-treated group Each rat received cisplatin (10mg/kg body weight) fractionated into three consecutive days by intraperitoneal injections (3.3mg/kg body weight /day) dissolved in normal saline then left for a month. d)- Cisplatin and Ginger-treated group In conclusion, the present study demonstrated that the ginger extract has a protective effect on the biochemical, histopathological, histochemical and ultrastructural and immunohistochemical changes induced by cisplatin chemotherapy in the kidney of albino rats. This is important when considering the possibility of using ginger for cisplatin-treated cancer patients to minimize its nephrotoxicity which is a major dose-limiting clinical problem.