الفهرس 
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Abstract
individuals who have a low T3 syndrome as those patients are more susceptible to morbidity and /or mortality during anesthesia .
This study was designed to demonstrate the effect of sevoflurane versus isoflurane anesthesia on thyroid function in normal versus diabetic patients .
This study was carried out on sixty patients (ASA physical status I or II), aged between 30 and 55 years undergoing vitreoretinal surgery.
Patients were randomly allocated into 2 equal groups (each of 30 patients) according to the inhaled volatile anesthetic:
The sevoflurane group (30 patients) which was subdivided into 2 groups each of 15 patients : group I (control group) and group II (controlled diabetic group), and The isoflurane group (30 patients) which was subdivided into 2 groups each of 15 patients : group III (control group) and group IV(controlled diabetic group).
In conclusion inhalation anesthetics can cause changes in the plasma level of thyroid hormones. The effects of sevoflurane on thyroid function are quite different from that of isoflurane. This is evidenced by a more release of FT3 with sevoflurane than with isoflurane. This could be attributed to a different molecular effect of both inhalation anesthetics at the receptor or the membrane level. The cause is the molecular and cellular effects of anesthetics, which needs to be clarified. Moreover, both inhalation anesthetics exhibit a different endocrinal and hemodynamic action on diabetic patients in comparison with normal individuals.